When running PS 4.0 or 4.5 and WebInterface 4.X and Pass-Thru authenticatio is enabled clients using ICA Client 10.15 will not be able to connect to Published Desktops.  Published Apps do work properly.  The error is "ICA Client Configuration Manager: Could not find the file named (C:\...\launch.ica).  Error 2306.  See imag below:

The problem is specific to Internet Explorer v6 and 7 with v10.15 of the ICA client. A workaround is to make the following registry change on the Client workstation:
Change the registry value HKEY_LOCAL_MACHINE\SOFTWARE\Citrix\ICA Client\Engine\Lockdown Profiles\All Regions\Lockdown\Client Engine\ICA File

Reg_SZ == RemoveICAFile
Change from "*" to "False"
Value == False